If acetaminophen is consumed in high doses, it can trigger permanent damage to the liver, while an overdose and even prove to be fatal. The vital aspect to remember is that the symptoms of acetaminophen overdose typically take two days to appear. The condition is profoundly urgent and must be treated promptly. Now, the initial two signs of such overdoses are extreme nausea and yellowing of the skin. However, overdosing with Fioricet involves a combination of all the symptoms triggered by butalbital, acetaminophen, and caffeine. Overdosing for taking barbiturates possibly causes cognitive disorders, severe fatigue, comatose states, dyspnea, and hallucinations. Now, the treatment must be started immediately, as butalbital can impact the essential areas of the brain. The high doses of caffeine can trigger seizures, acute diarrhea, and excessive perspiration.

Hence, it is highly advisable to use Fioricet with prior consultation with your physician. Nevertheless, before having this drug, it is justified to tell your doctor, whether you have a medical history of abuse from substances, alcohol addiction, or have suffered from respiratory ailment. Along with these, patients should also mention liver ailment, depression, and porphyria. Thus, butalbital is not recommended for use in severe metabolic disorders of porphyria. Again, Fioricet can also trigger interaction with different types of drugs, including benzodiazepines, blood thinners, tricyclic antidepressants, and narcotic pain medicine. One needs to take advice from their physician regarding such medications. Moreover, one should remember that butalbital can potentially impact the central nervous system, and its effect can be increased if the patient is having MAO inhibitors simultaneously.